Researchers at National Jewish Health have discovered specific molecular and signaling (cellular communication) events by which vitamin D inhibits inflammation. In their experiments, they showed that low levels of Vitamin D, comparable to levels found in millions of people, failed to inhibit the inflammatory cascade (response in the body), while levels considered adequate did inhibit inflammatory signaling. They reported their results in the March 1, 2012, issue of The Journal of Immunology.

Here are some excerpts from the ScienceDaily article:

Through a complex series of experiments, the researchers identified a new location where the vitamin-D receptor appears to bind directly to DNA and activate a gene…..that ….interferes with the inflammatory cascade (response).

“This newly identified DNA-binding site for the vitamin-D …, and the specific (inflammation) pathways inhibited by higher levels of vitamin D provide a plausible mechanism for many of the benefits that have been associated with vitamin D,” said Dr. Goleva. ‘The fact that we showed a dose-dependent and varying response to levels commonly found in humans also adds weight to the argument for vitamin D’s role in immune and inflammatory conditions.”

Comment from the blog author Nutrition Breakthroughs:

Vitamin D has been found to be beneficial for many health conditions such as increasing calcium absorption, strengthening bones, and reducing cancer risk. According to the National Institutes of Health, vitamin D might play some role in the prevention and treatment of type 1 and type 2 diabetes, high blood pressure, glucose intolerance, multiple sclerosis, and other medical conditions.

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